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Research

There's four key research themes at Alder HeyAcute infection is the leading single cause of death in childhood in the UK, being responsible for about 15% of childhood deaths. We are an established centre of excellence in infectious diseases.

Along with the University of Liverpool, we have brought together leading infection researchers into a single new Institute of Infection and Global Health.

Research impact – Identifying serious infection promptly in children

Researchers from the University of Liverpool are working with commercial partners to develop a rapid bedside test for the early detection of sepsis.

The diagnosis of sepsis can be difficult, because in the early stages, signs and symptoms are non-specific. Sepsis claims over 37,000 lives in the United Kingdom annually – more than lung cancer and more than breast cancer and bowel cancer combined. Early recognition and intervention saves lives, and may save as many as 15,000 lives annually in the UK per year.

The novel bedside test uses a combination of blood markers to detect bacterial infection, and it is hoped that the test will be performed on a simple finger prick blood sample to give a result within two minutes.

Early results show that the innovative test is much better at diagnosing septicaemia (which is life-threatening) than currently used tests, and could therefore potentially save lives and prevent complications such as limb loss.

Key areas of study

  • Biomarkers of Infection
  • Respiratory Virus Infections
  • Improving lives of children with Cystic Fibrosis
  • Stratified medicines
  • Asthma
  • Infections with Children with congenital abnormalities
  • Severe infections in Children
  • Antimicrobial studies in children

Meet the Team

The Infection research theme team comprises:

Theme Lead

Dr Enitan Carrol

Respiratory virus infections

Dr Paul McNamara, Brian Flanagan

Improving the lives of children with CF

Dr Kevin Southern

Biomarkers of Infection

Dr Enitan Carrol

Severe Acute Respiratory Infection (SARI) in the wider community

Dr Calum Semple

Mechanisms of Disease

Dr Brian Flanagan, Paul McNamara

Stratified Medicine

Dr Enitan Carrol

Antimicrobial studies

Dr Stephane Paulus

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