Medicines research in paediatrics is an important component of the Integrated Research Strategy for Child Health and a key contributor to the Liverpool Health Partners Clinical Academic Programme in Drugs.
The theme is supported by major institutions, units and infrastructure awards:
- NIHR Clinical Research Network: Children
- NIHR Alder Hey Clinical Research Facility for Experimental Medicine
- Wolfson centre for Personalised Medicine, University of Liverpool
- Centre for Drug Safety Sciences, University of Liverpool
- Medicines for Children Clinical Trials Unit, University of Liverpool
The research programme covers a range of paediatric sub-specialities, with important collaborations with neonatal medicine through Liverpool Women’s NHS Foundation Trust and the Institute of Translational Medicine, University of Liverpool. The team collaborates with clinical pharmacologists within the Department of Molecular and Clinical Pharmacology at the University of Liverpool including a development programme for aspiring paediatric clinical pharmacologists, and has recently appointed a Senior Lecturer in Paediatric Clinical Pharmacology.
The focus of the research programme is on drug development and early phase studies in children, development of novel methodologies for pharmacokinetic/paharmacodynamic modelling in children and infants, pharmacogenetics, paediatric pharmacovigilance and paediatric drug formulation sciences. The programme includes partnership within major international research initiatives, including the EU funded Network of Excellence – Global Research in Paediatrics (GRiP).
Key areas of study
- Drug Safety Sciences
- Clinical Pharmacology
- Stratified medicines
- Child & Family Involvement
- Study Delivery & Research Facilitation
Manipulation of Drugs Required in Children (MODRIC)
This guideline presents the available evidence on manipulation of medicines to achieve a proportional dose and aims to describe interventions that may avoid the need to manipulate medicines.
Where manipulation is considered necessary this guideline aims to provide accessible, dosage form specific guidance, for undertaking manipulations and provides guidance on avoiding manipulations (where possible) and medicines that should not be manipulated.
Meet the Team
The Children’s Medicines research theme team comprises:
Professor Matthew Peak: Matthew.Peak@alderhey.nhs.uk
Leads for Paediatric Medicines Research Unit
- Dr Mark Turner: Mark.Turner@liv.ac.uk
- Professor Tony Nunn: A.J.Nunn@liv.ac.uk
- Professor Matthew Peak: Matthew.Peak@alderhey.nhs.uk
Clinical Director of NIHR Alder Hey Clinical Research Facility
Professor Michael Beresford: M.W.Beresford@liv.ac.uk
Director of Pharmacy
Catrin Barker: Catrin.Barker@alderhey.nhs.uk
Senior Research Pharmacist
Jenny Bellis: Jennifer.Bellis@alderhey.nhs.uk
Senior Lecturer in Paediatric Clinical Pharmacology
Dr Dan Hawcutt: email@example.com
GRiP Research Pharmacist
Jennifer Duncan: Jennifer.Duncan@alderhey.nhs.uk
Lead for Antimicrobial Pharmacodynamics and Theraputics
Professor William Hope: William.Hope@liv.ac.uk