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Research

Medicines research in paediatrics is an important component of the Integrated Research Strategy for Child Health and a key contributor to the Liverpool Health Partners Clinical Academic Programme in Drugs.

The theme is supported by major institutions, units and infrastructure awards:

Medicines of the future artwork, created by children treated at Alder HeyThe research programme covers a range of paediatric sub-specialities, with important collaborations with neonatal medicine through Liverpool Women’s NHS Foundation Trust and the Institute of Translational Medicine, University of Liverpool. The team collaborates with clinical pharmacologists within the Department of Molecular and Clinical Pharmacology at the University of Liverpool including a development programme for aspiring paediatric clinical pharmacologists, and has recently appointed a Senior Lecturer in Paediatric Clinical Pharmacology.

 

The focus of the research programme is on drug development and early phase studies in children, development of novel methodologies for pharmacokinetic/paharmacodynamic modelling in children and infants, pharmacogenetics, paediatric pharmacovigilance and paediatric drug formulation sciences. The programme includes partnership within major international research initiatives, including the EU funded Network of Excellence – Global Research in Paediatrics (GRiP).

Key areas of study

  • Drug Safety Sciences
  • Clinical Pharmacology
  • Stratified medicines
  • Pharmacy
  • Neonates
  • Child & Family Involvement
  • Study Delivery & Research Facilitation

Manipulation of Drugs Required in Children (MODRIC)

This guideline presents the available evidence on manipulation of medicines to achieve a proportional dose and aims to describe interventions that may avoid the need to manipulate medicines.

Where manipulation is considered necessary this guideline aims to provide accessible, dosage form specific guidance, for undertaking manipulations and provides guidance on avoiding manipulations (where possible) and medicines that should not be manipulated.

Meet the Team

The Children’s Medicines research theme team comprises:

Theme Lead

Professor Matthew Peak:  Matthew.Peak@alderhey.nhs.uk

Leads for Paediatric Medicines Research Unit

Clinical Director of NIHR Alder Hey Clinical Research Facility

Professor Michael Beresford: M.W.Beresford@liv.ac.uk

Director of Pharmacy

Catrin Barker: Catrin.Barker@alderhey.nhs.uk

Senior Research Pharmacist

Jenny Bellis: Jennifer.Bellis@alderhey.nhs.uk

Senior Lecturer in Paediatric Clinical Pharmacology

Dr Dan Hawcutt: d.hawcutt@liverpool.ac.uk

GRiP Leads

GRiP Research Pharmacist

Jennifer Duncan: Jennifer.Duncan@alderhey.nhs.uk

Lead for Antimicrobial Pharmacodynamics and Theraputics

Professor William Hope: William.Hope@liv.ac.uk

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